敖航，理学博士，硕士生导师。2024年博士毕业于南京大学化学化工学院化学专业，导师:鞠焜先教授。2024年9月加入贵州师范大学化学与材料科学学院工作至今。博士期间的研究课题为主要从事化学发光免疫传感器的构建、高效化学发光体系的研究和化学发光微流控芯片的开发等相关工作，后期重点研究金属-有机框架材料(MOFs)及金属合金纳米酶的催化化学发光机制研究及过程调控，并探索此类材料在化学发光生物传感中的应用。目前已在Analytical Chemisty、Sensors and Actuators: B. Chemical, Communications Biology, Biosensors and Bioelectronics 等发表论文共28篇，其中以第一作者发表论文10篇，共同一作发表3篇，申请专利4项，授权专利1项。
联系方式：hao@gznu.edu.cn
一、研究方向
（1）生物传感器开发及疾病标志物检测
（2）核酸信号放大技术开发及生物传感应用
二、科研项目
（1）贵州省基础研究计划面上项目，2026.01-2028.12，主持；
（2）贵州省科技厅基础研究计划青年引导项目，2025.01-2027.12，主持；
（3）南京大学“生命分析化学全国重点实验室”2025年度批准开放课题，2025.05-2027.05，主持。
三、学术成果
1. Hang Ao, Zhaosheng Qian, Yuyu Zhu, Meizhi Zhao, Cong Tang, Yuanyuan Huang, Hui Feng*, Aijun Wang*. A fluorometric biosensor based on functional Au/Ag nanoclusters for real-time monitoring of tyrosinase activity. Biosens. Bioelectron. 2016, 86, 542-547. (一区，Top， IF=12.6) DOI: 10.1016/j.bios.2016.07.051
2. Yuanyuan Huang, Hui Feng, Weidong Liu, Yingying Zhou, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong Chen, Zhaosheng Qian. Luminescent aggregated copper nanoclusters nanoswitch controlled by hydrophobic interaction for real-time monitoring of acid phosphatase activity. Anal. Chem. 2016, DOI: 10.1021/acs.analchem.6b02957
3. Yuanyuan Huang, Weidong Liu, Hui Feng, Yangting Ye, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong Chen, Zhaosheng Qian. Luminescent Nanoswitch Based on Organic-Phase Copper Nanoclusters for Sensitive Detection of Trace Amount of Water in Organic Solvents. Anal. Chem. 2016, DOI: 10.1021/acs.analchem.6b02149.
4. Yuanyuan Huang, Jin Zhou, Hui Feng, Jieyu Zheng, Hui-Min Ma, Weidong Liu, Cong Tang, Hang Ao, Meizhi Zhao, Zhaosheng Qian. A dual-channel fluorescent chemosensor for discriminative detection of glutathione based on functionalized carbon quantum dots. Biosens. Bioelectron. 2016, DOI: 10.1016/j.bios.2016.07.081
5. Cong Tang, Zhaosheng Qian, Yuanyuan Huang, Jiamin Xu, Hang Ao, Meizhi Zhao, Jin Zhou, Jianrong Chen, Hui Feng. A fluorometric assay for alkaline phosphatase activity based on β-cyclodextrin-modified carbon quantum dots through host-guest recognition. Biosens. Bioelectron. 2016,
6. Hang Ao, Hui Feng, Meizhi Zhao, Jianrong Chen, Zhaosheng Qian*. Redox-triggered bonding-induced emission of thiol-functionalized gold nanoclusters for luminescence turn-on detection of molecular oxygen. ACS Sens. 2017, 2, 1692-1699. (一区，Top， IF=8.9)
7. Hang Ao, Hui Feng, Xiaolu Huang, Meizhi Zhao, Zhaosheng Qian*. A reversible fluorescence nanoswitch based on dynamic covalent B–O bonds using functional carbon quantum dots and its application for a-glucosidase activity monitoring. J. Mater. Chem. C 2017, 5, 2826-2832. (二区，IF=6.467)
8. Meizhi Zhao, Hui Feng, Xiaoxiao Zhang, Hang Ao and Zhaosheng Qian. Bonding-induced emission of silyl-protected copper nanoclusters for luminescence turn-on detection of trace water in organic solvents. Analyst 2017, DOI: 10.1039/c7an01542a
9. Meizhi Zhao, Hui Feng, Jiaonan Han, Hang Ao, Zhaosheng Qian. Multi-stimuli responsive copper nanoclusters with bright red luminescence for quantifying acid phosphatase activity via redox-controlled luminescence switch. Anal. Chim. Acta 2017, DOI: 10.1016/j.aca.2017.06.046
10. Meizhi Zhao, Zhaosheng Qian, Mengting Zhong, Zhentian Chen, Hang Ao, Hui Feng. Fabrication of stable and luminescent copper nanocluster-based aie particles and their application in β-galactosidase activity assay. Anal. Chim. Acta 2017, DOI: 10.1021/acsami.7b09659
11. Cong Tang, Zhaosheng Qian, Yinjie Qian, Yuanyuan Huang, Meizhi Zhao, Hang Ao, Hui Feng. A fluorometric and real-time assay for α-glucosidase activity through supramolecular self-assembly and its application for inhibitor screening. Sens. Actuator B-Chem. 2017, DOI: 10.1016/j.snb.2017.01.150
12. Hang Ao, Hui Feng, Keqing Li, Meizhi Zhao, Zhaosheng Qian*, Jianrong Chen*. Coordinate bonding-induced emission of gold-glutathione complex for sensitive detection of aluminum species. Sens. Actuator B-Chem. 2018, 272, 1-7. (一区，Top， IF=8.4).
13. Hang Ao, Hui Feng, Saifei Pan, Zhiyi Bao, Zhenhui Li, Jianrong Chen, Zhaosheng Qian*. Synthesis and functionalization of stable and bright copper nanoclusters by in situ generation of silica shells for bioimaging and biosensing. ACS Appl. Eng. Mater. 2018, 1, 5673−5681. (三区，IF=6.140)
14. Rui Zhang, Jie Wu, Hang Ao, Jinling Fu, Bin Qiao, Qiang Wu, Huangxian Ju. A rolling circle-amplified G-quadruplex/hemin DNAzyme for chemiluminescence immunoassay of the SARS-CoV-2 protein. Anal. Chem. 2021, 93, 9933−9938.
15. Hang Ao, Weiwei Chen, Jie Wu*, Wencheng Xiao, Huangxian Ju*. Chemiluminescent screening of specific hybridoma cells via a proximity-rolling circle activated enzymatic switch. Commun. Bio. 2022, 5, 308. (一区，Top，IF=6.548)
16. Ningning Wang, Hang Ao (共同一作), Wencheng Xiao, Hang Gao, Jianping Lei, Huangxian Ju*. Confned electrochemiluminescence imaging microarray for high-throughput biosensing of single cell-released dopamine. Biosens. Bioelectron. 2022, 201, 113959. (一区，Top， IF=12.6)
17. Yuhui Chen, Hang Ao (共同一作?), Wencheng Xiao, Huangxian Ju*, Jie Wu*. Chemiluminescent imaging assay of SARS-CoV-2 protein with target induced enzyme activity regulation. Chem. Eur. J. 2022, 28, e202201425. (三区， IF=4.3)
18. Dong Wang, Chengtao Chen, Jun Sun, Hang Ao, Wencheng Xiao, Huangxian Ju*, Jie Wu*. Refillable fuel-loading microshell motors for persistent motion in a fuel-free environment. ACS Appl. Mater. Interfaces 2022. 14, 27074-27082. (二区，IF=9.5)
19. Hang Ao, Wencheng Xiao, Yuhui Chen, Jie Wu*, Huangxian Ju*. Target-triggered parallel rolling circle amplifcation circuits for chemiluminescent imaging assay of proteins. Sens. Actuator B-Chem. 2023, 383, 133579. (一区，Top， IF=8.4)
20. Yao Shi, Jie Wu, Wenxing Wu, Nini Luo, Hao Huang, Yuhui Chen, Jun Sun, Qian Yu, Hang Ao, Qiqi Xu, Xiaotian Wu, Qianfeng Xia*, Huangxian Ju*. AuNPs@MoSe2 heterostructure as a highly efficient coreaction accelerator of electrocheluminescence for amplified immunosensing of DNA methylation. Biosens. Bioelectron. 2023, 222, 114976. (一区，Top， IF=12.6)
21. Hang Ao, Wencheng Xiao, Wenrui Hu, Jie Wu*, Huangxian Ju*. DNA conformation-regulated hemin switch for lab-on-chip chemiluminescent detection of an antibody secreted from hybridoma cells. Anal. Chem. 2024, 96, 18502–18509. (一区，Top， IF=6.7)
22. Wenrui Hu, Hang Ao (共同一作), Ziyi Lv, Wencheng Xiao, Wei Li, Jianping Lei, Jie Wu*, Huangxian Ju. Glow-type luminol chemiluminescence based on a supramolecular enhancer of cyclodextrin. Anal. Chim. Acta 2024, 1328, 343182. (二区， IF=5.7)
23. Raril Chenthattil , Sijian Luo , Hang Ao , Wencheng Xiao , Huangxian Ju. Layer-by-layer assembled film of TiO2/poly(l-lysine)/graphene quantum dots for simultaneous electrochemical determination of guanine and adenine. 2024, 967, 118482.
24. Sijian Luo, Jie Wu, Min Zhong, Jun Sun, Hang Ao, Xu Cao, Jinbo Liu*, Huangxian Ju*. An electrochemiluminescent imaging strategy based on CRISPR/Cas12a for ultrasensitive detection of nucleic acid. Anal. Chim. Acta 2024, 1324, 343040.
25. Jun Sun, Ran Chu, Xiaoqian Wu, Qian Yu, Wencheng Xiao, Hang Ao, Yuru Wang, Taikang Wu, Huangxian Ju, Jie Wu, Jianping Lei. Anti-Biopassivated Reticular Micromotors for Bladder Cancer Therapy. J. Am. Chem. Soc. 2025, 147, 17936–17945.
26. Hang Ao, Wencheng Xiao, Weiwei Chen, Wenrui Hu, Jie Wu,* and Huangxian Ju*. A Microcavity Chemiluminescent Immunoimaging Protocol for Fast In Situ Detection of Antibody Secreted from Single Hybridoma Cells. Small methods 2025, 2500656.
27. Hang Ao, Jinshan Xiong, Wencheng Xiao, Wenrui Hu, Jie Wu*, Huangxian Ju*. Imidazole-enhanced luminol/H2O2 chemiluminescent biosensing for SARS-CoV-2 nucleocapsid protein with enzymatic regulation of hemin switch. Biosens. Bioelectron. 2025, 290, 118002.
28. Wencheng Xiao, Hang Ao (共同一作), Nilin Wu, Jun Sun, Wenrui Hu, Yunlong Chen, Jie Wu, Huangxian Ju. Hemin-DNA Switch-Assisted Microfluidic Chemiluminescence Immunoimaging for Rapid and Quantitative Screening of Specific Hybridomas. Anal. Chem.2026, 98, 2541–2549.
29. 敖航，肖文成，胡文瑞，吴洁*，鞠熀先*，基于咪唑增强的化学发光成像方法用于单细胞分泌抗体的原位检测。分析化学岳麓前沿论坛，长沙，2023。
申请
1. 鞠熀先，吴洁，敖航，滚环扩增诱导酶活性开关激活的方法，202110771113.1。申请日期：2021年7月8日。
2. 鞠熀先，吴洁，敖航，基于邻位诱导免疫分析的特异性杂交瘤细胞化学发光筛选方法，202110771111.2。申请日期：2021年7月8日。
3. 鞠熀先，吴洁，敖航，基于DNA放大的蛋白质化学发光成像检测方法和试剂盒，202210583817.0。申请日期：2022年5月27日。
